英国上市公司365畜牧学研究生

导师黄桂安简介

个人简介： 黄桂安，博士，硕士生导师。天津市131创新型人才培养工程第三层次。主要研究方向为动物发育与繁殖生物学，动物遗传育种。主持国家自然科学基金1项，以项目骨干参与国家重点研发计划1项，发表SCI论文16余篇。

研究方向：动物遗传育种与繁殖，精子发生

学习工作经历：

学习经历

2012-09 至 2015-06, 四川大学, 细胞生物学, 博士

2009-09 至 2012-06, 四川大学, 细胞生物学, 硕士

2005-09 至 2009-06, 四川大学, 生物科学, 学士

工作经历

2025-03至今 英国365官方网站 英国上市公司365 讲师

2019-07 至2025-02 英国365官方网站生命科学学院 讲师

2015-07 至2019-06 南开大学 生命科学学院 讲师

科学研究：

科研项目：

1. 海藻源单糖/寡糖缓解霉菌毒素生殖毒害及在种猪养殖中的应用，参与
2. 科技特派员行动计划项目-里岔黑猪重要经济性状基因组选育技术创新与应用示范，参与
3. 乙酰胆碱受体M5在小鼠卵母细胞发育过程中的作用及机制研究，山东省自然科学基金面上项目，参与
4. 乙酰胆碱M5受体通过调节细胞间连接来调控精子发生的机制，国家自然科学基金面上项目，参与
5. 线粒体遗传疾病治疗的辅助生殖新技术研究，国家重点研发计划，项目骨干
6. Tet1/Tet2敲除影响小鼠精原干细胞自我更新和多能性及其分子机制，国家自然科学基金青年项目，主持

发表论文

1. Huang G, Liu L, Wang H, Gou M, Gong P, Tian C, Deng W, Yang J, Zhou TT, Xu GL, Liu L. Tet1 Deficiency Leads to Premature Reproductive Aging by Reducing Spermatogonia Stem Cells and Germ Cell Differentiation. iScience. 2020 Mar 27;23(3):100908. doi: 10.1016/j.isci.2020.100908. Epub 2020 Feb 13. PMID:32114381; PMCID: PMC7049665.
2. Wang H, Liu L, Gou M, Huang G, Tian C, Yang J, Wang H, Xu Q, Xu GL, Liu L. Roles of Tet2 in meiosis, fertility and reproductive aging. Protein Cell. 2021 Jul;12(7):578-585. doi: 10.1007/s13238-020-00805-8. Epub 2020 Nov 20. PMID: 33216286; PMCID: PMC8225707.

3. Huang G, He C, Meng F, Li J, Zhang J, Wang Y. Glucagon-like peptide (GCGL) is a novel potential TSH-releasing factor (TRF) in Chickens: I) Evidence for its potent and specific action on stimulating TSH mRNA expression and secretion in the pituitary. Endocrinology. 2014 Nov;155(11):4568-80. doi:10.1210/en.2014-1331. Epub 2014 Jul 30. PMID: 25076122.

4. Huang G, Li J, Wang H, Lan X, Wang Y. Discovery of a novel functional leptin protein (LEP) in zebra finches: evidence for the existence of an authentic avian leptin gene predominantly expressed in the brain and pituitary. Endocrinology. 2014 Sep;155(9):3385-96. doi: 10.1210/en.2014-1084. Epub 2014 May 13. PMID: 24823393.
5. Meng F, Huang G, Gao S, Li J, Yan Z, Wang Y. Identification of the receptors for somatostatin (SST) and cortistatin (CST) in chickens and investigation of the roles of cSST28, cSST14, and cCST14 in inhibiting cGHRH1-27NH2-induced growth hormone secretion in cultured chicken pituitary cells. Mol Cell Endocrinol. 2014 Mar 25;384(1-2):83-95. doi: 10.1016/j.mce.2014.01.001. Epub2014 Jan 10. PMID: 24418361.
6. Bu G, Huang G, Fu H, Li J, Huang S, Wang Y. Characterization of the novel duplicated PRLR gene at the late-feathering K locus in Lohmann chickens. J Mol Endocrinol. 2013 Sep 13;51(2):261-76. doi: 10.1530/JME-13-0068. PMID: 23940279.
7. Bu G, Ying Wang C, Cai G, Leung FC, Xu M, Wang H, Huang G, Li J, Wang Y. Molecular characterization of prolactin receptor (cPRLR) gene in chickens: gene structure, tissue expression, promoter analysis, and its interaction with chicken prolactin (cPRL) and prolactin-like protein (cPRL-L). Mol Cell Endocrinol. 2013 May 6;370(1-2):149-62. doi: 10.1016/j.mce.2013.03.001. Epub 2013 Mar 14. PMID: 23499864.
8. Wang Y, Meng F, Zhong Y, Huang G, Li J. Discovery of a novel glucagon-like peptide (GCGL) and its receptor (GCGLR) in chickens: evidence for the existence of GCGL and GCGLR genes in nonmammalian vertebrates. Endocrinology. 2012 Nov;153(11):5247-60. doi: 10.1210/en.2012-1586. Epub 2012 Sep 26. PMID:23015292.
9. Wang Y, Wang CY, Wu Y, Huang G, Li J, Leung FC. Identification of the receptors for prolactin-releasing peptide (PrRP) and Carassius RFamide peptide (C-RFa) in chickens. Endocrinology. 2012 Apr;153(4):1861-74. doi: 10.1210/en.2011-1719. Epub 2012 Feb 21. PMID: 22355069.
10. Wang Y, Huang G, Li J, Meng F, He X, Leung FC. Characterization of chicken secretin (SCT) and secretin receptor (SCTR) genes: a novel secretin-like peptide (SCT-LP) and secretin encoded in a single gene. Mol Cell Endocrinol. 2012 Jan 2;348(1):270-80. doi: 10.1016/j.mce.2011.09.012. Epub 2011 Sep 14. PMID:21939730.
11. Guo HY, Tang SB, Li LJ, Lin J, Zhang TT, Chao S, Jin XW, Xu KP, Su XF, Yin S, Zhao MH, Huang GA, Yang LJ, Shen W, Zhang L, Zhang CL, Sun QY, Ge ZJ. Gestational diabetes mellitus causes genome hyper-methylation of oocyte via increased EZH2. Nat Commun. 2025 Jan 2;16(1):127. doi: 10.1038/s41467-024-55499-x. PMID: 39747080; PMCID: PMC11696910.
12. Chao S, Lu J, Li LJ, Guo HY, Xu K, Wang N, Zhao SX, Jin XW, Wang SG, Yin S, Shen W, Zhao MH, Huang GA, Sun QY, Ge ZJ. Maternal obesity may disrupt offspring metabolism by inducing oocyte genome hyper-methylation via increased DNMTs. Elife. 2024 Dec 6;13:RP97507. doi: 10.7554/eLife.97507. PMID: 39642055; PMCID: PMC11623932.
13. Chao S, Li LJ, Lu J, Zhao SX, Zhao MH, Huang GA, Yin S, Shen W, Sun QY, Zhao Y, Ge ZJ, Zhao L. Corrigendum to "Epigallocatechin gallate improves the quality of diabetic oocytes" [Biomed. Pharmacother. 159 (2023) 114267]. Biomed Pharmacother. 2024 Aug;177:117096. doi: 10.1016/j.biopha.2024.117096. Epub 2024 Jul 5. Erratum for: Biomed Pharmacother. 2023 Mar;159:114267. doi: 10.1016/j.biopha.2023.114267. PMID: 38969553.
14. Chao S, Li LJ, Lu J, Zhao SX, Zhao MH, Huang GA, Yin S, Shen W, Sun QY, Zhao Y, Ge ZJ, Zhao L. Epigallocatechin gallate improves the quality of diabetic oocytes. Biomed Pharmacother. 2023 Mar;159:114267. doi: 10.1016/j.biopha.2023.114267. Epub 2023 Jan 18. Erratum in: Biomed Pharmacother. 2024 Aug;177:117096. doi: 10.1016/j.biopha.2024.117096. PMID: 36669363.
15. Li LJ, Chao S, Zhao SX, Lu J, Zhang XY, Zhao Y, Zhao MH, Huang GA, Yin S, Sun QY, Zhao L, Ge ZJ. Protocatechuic Acid Delays Postovulatory Oocyte Ageing in Mouse. Mol Nutr Food Res. 2023 Feb;67(4):e2200363. doi: 10.1002/mnfr.202200363. Epub 2023 Jan 26. PMID: 36537853.
16. Gai Y, He ZJ, Wang SG, Wang N, Ge ZJ, Huang G, Shen W, Yin S, Zhao M. Epigallocatechin gallate improves meiosis maturation against Diazinon exposure in porcine oocytes. Theriogenology. 2023 Jan 15;196:1-9. doi: 10.1016/j.theriogenology.2022.09.016. Epub 2022 Sep 18. PMID: 36371914.

教学授课情况： 主讲《动物学》、《动物学实验》、《动物学实习》、《细胞工程》等

获奖及社会兼职等情况：

获奖情况：

天津市131创新型人才培养工程第三层次

英国365官方网站第四届“最受欢迎本科任课教师”

联系方式：邮箱:378036847@qq.com 电话:13356895513